2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5 Tolvaptan Intermediate Factory High Quality

Short Description:

Chemical Name: 2-Methyl-4-Nitrobenzoic Acid 

CAS: 1975-51-5

Purity: ≥98.0% (HPLC)

Appearance: Almost White or Pale Yellow Crystal Powder

Intermediate of Tolvaptan (CAS 150683-30-0) for the treatment of Hyponatremia

Inquiry: alvin@ruifuchem.com  

Product Detail

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Chemical Properties:

Chemical Name 2-Methyl-4-Nitrobenzoic Acid
Synonyms 4-Nitro-o-Toluic Acid; 4-Nitro-2-Methylbenzoic Acid 
CAS Number 1975-51-5
CAT Number RF-PI397
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C8H7NO4
Molecular Weight 181.15
Brand Ruifu Chemical


Item Specifications
Appearance Almost White or Pale Yellow Crystal Powder
1H-NMR Consistent with Structure
Purity / Analysis Method ≥98.0% (HPLC) 
Melting Point 153.0~156.0℃
Moisture (K.F) ≤0.50%
Residue on Ignition ≤0.50%
Total Impurities ≤2.0%
Test Standard Enterprise Standard
Usage Intermediate of Tolvaptan (CAS 150683-30-0)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.





2-Methyl-4-Nitrobenzoic Acid (CAS 1975-51-5) is used as a pharmaceutical intermediate in the synthesis of Tolvaptan (CAS 150683-30-0). Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. Tolvaptan is used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca.

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