Tolvaptan CAS 150683-30-0 API Purity >99.0% (HPLC)

Short Description:

Chemical Name: Tolvaptan 

CAS: 150683-30-0

Purity (HPLC): >99.0%

Appearance: White to Off-White Crystalline Powder

A potent and selective vasopressin V2 receptor antagonist

API High Quality, Commercial Production


Product Detail

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Chemical Properties:

Name Tolvaptan
Chemical Name N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide
CAS Number 150683-30-0
CAT Number RF-API101
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C26H25ClN2O3
Molecular Weight 448.94
Brand Ruifu Chemical


Item Specifications
Appearance White to Off-White Crystalline Powder
Identification Methods IR, HPLC
Solubility Soluble in Benzyl Alcohol and Methanol but Practically Insoluble in Water and Hexane
Purity / Analysis Method >99.0% (HPLC)
Melting Point 219.0~222.0℃
Loss on Drying <0.50%
Residue on Ignition <0.10%
Single Impurity <0.50%
Total Impurities <1.00%
Heavy Metals ≤20ppm
Residual Solvents Meet the Specification
Test Standard Enterprise Standard
Usage API; Pharmaceutical Intermediates

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture





Tolvaptan (CAS: 150683-30-0), also known as OPC-41061, is a selective, competitive arginine vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Otsuka Pharmaceutical licensed tolvaptan under the trade name Samsca after the FDA approved the drug in May 2009. Tolvaptan has also shown efficacy against polycystic kidney disease. In a 2004 trial, tolvaptan administered with traditional diuretics was noted to increase excretion of excess fluids and improve blood sodium levels in patients with heart failure without producing side effects such as hypotension (low blood pressure) or hypokalemia (decreased blood levels of potassium). The drug also exhibited no adverse effect on kidney function.

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