Tolvaptan CAS 150683-30-0 API Falegaosi Mea Maualuluga
Sapalai a le Kamupani
Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau: Tolvaptan
CAS: 150683-30-0
| Igoa | Tolvaptan |
| Igoa Kemisi | N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide |
| Numera CAS | 150683-30-0 |
| CAT Numera | RF-API101 |
| Tulaga Fa'asoa | O lo'o iai fa'aputuga, Fa'ato'a o'o atu i Tone |
| Fuafua mole | C26H25ClN2O3 |
| Molecular Weight | 448.94 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e tioata |
| Faiga Fa'ailoa | IR, HPLC |
| Su'ega (HPLC) | 98.0~102.0% (i luga ole fa'avae) |
| Lisimea | 219.0~222.0 ℃ |
| Ma'imau ile Fa'agogo | ≤0.50% |
| Toega i luga o le mumu | ≤0.10% |
| Le mama nofofua | ≤0.50% |
| Aofa'i Fa'aleaga | ≤1.0% |
| Uamea Mamafa | ≤20ppm |
| Solvents totoe | Faʻafeiloaʻi le Faʻamatalaga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Vailaau Fa'atekonolosi |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu.
Tolvaptan (CAS 150683-30-0), e taʻua foi o le OPC-41061, o se tagata faʻatauvaʻa faʻatauvaa arginine vasopressin receptor 2 faʻaaogaina e togafitia ai le hyponatremia (maualalo o le toto sodium maualuga) e fesoʻotaʻi ma le faʻaletonu o le fatu, cirrhosis, ma le maʻi o le le talafeagai. hormone fa'ama'i (SIADH).Otsuka Pharmaceutical laisene tolvaptan i lalo o le igoa tau fefa'ataua'iga Samsca ina ua mae'a fa'amaonia e le FDA le vaila'au ia Me 2009. Ua fa'aalia fo'i e Tolvaptan le aoga i le fa'ama'i fatuga'o polycystic.I se faʻataʻitaʻiga i le 2004, o le tolvaptan na faʻaaogaina faʻatasi ma vailaʻau faʻaleaganuʻu na matauina e faʻateleina ai le faʻaogaina o le tele o vai ma faʻaleleia le maualuga o le sodium toto i tagata mamaʻi maʻi fatu e aunoa ma le faia o aʻafiaga e pei o le toto maualuga (maualalo le toto) poʻo le hypokalemia (faʻaitiitia le maualuga o le toto o le potassium).O le vailaʻau foʻi na faʻaalia e leai se aʻafiaga leaga i le gaioiga o fatugaʻo.
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